Evaluation of The Effects of Laboratory Values, Oxidation Parameters, Scoring Systems, and Ventricular Diameter Measurements on Prognosis in Patients Diagnosed with APE in The Emergency Department

Objective: This study aimed to investigate the role of oxidant and antioxidant levels in the diagnosis of acute pulmonary embolism (APE).
Material and Methods: Participants diagnosed with APE were included in group 1, and healthy volunteers were included in Group 2. In addition, Group 1 was divided into two groups according to 30-day mortality.
Results: Sixty-five participants diagnosed with APE were included in Group 1. A total of 52 healthy volunteers were included in Group 2. The total antioxidant capacity (TAC) levels of Group 1 were lower than those of Group 2, and the total oxidant capacity (TOC), oxidative stress index (OSI), and ischemia-modified albumin levels were higher. When receiver operating characteristic analysis was performed for TAC, TOC, OSI, and ischemia-modified albumin, the highest area under the curve was found for OSI, TOC, and ischemia-modified albumin, respectively. Fifteen (23%) participants in Group 1 died within 30 days of admission to the emergency department (Group 1A), and 50 (77%) survived after 30 days (Group 1B).
Conclusion: The oxidant-antioxidant balance is impaired in APE. Therefore, oxidants and antioxidants can be used to diagnose and exclude patients with suspected APE.

Keywords: Antioxidant, ischemia, oxidant, oxidative stress, pulmonary embolism